Conflicting Data on Efficacy of Cannabinoids for Epilepsy

Clobazam doesn’t make CBD work any better, says one study.

CBD doesn’t help clobazam reduce seizures, says another.

Clobazam may reduce seizures but not enough evidence, says another.

CBD and clobazam work together to reduce seizures, says yet another.

Clobazam didn’t work?

The benzodiazepine clobazam does not appear to help reduce seizure frequency and severity in people taking CBD or Epidiolex for epilepsy, according to new research out of the University of Alabama’s Department of Neurology.

…when participants on CBD + clobazam were compared with those taking CBD only, there were no significant differences in the frequency and severity of seizures. 

Study participants were separated into two groups — one taking CBD + clobazam and the other taking CBD only.

All groups saw significant reductions in seizure frequency and severity, said the authors of the study.

“These analyses suggest that concomitant to CBD, AEDs (anti-epileptic drugs) may not have an effect on reducing seizure frequency and severity in patients with TRE (treatment-resistant epilepsy),” the study said.

The study was published in Epilepsy and Behavior in August 2019.

CBD doesn’t work?

Meanwhile, another study out of the Netherlands arrived at a different conclusion, saying CBD made little or no difference to treatment with clobazam, a benzodiazepine that can be addictive for some people.

But then again … Clozabam may work

It remains unclear which patients will best benefit from clobazam and over what time-frame.

Another recent study from the UK found that: “When used as add-on therapy, Clobazam may reduce seizure frequency and may be most effective in focal-onset seizures.”

The paper cautions that reader that the finding was derived from “very low-quality evidence and from studies judged to have an unclear risk of bias.”

The study said it remains unclear which patients will best benefit from clobazam and over what time-frame.

The authors say a large-scale, randomised controlled trial to is needed “to effectively inform clinical practice.”

It’s always possible that … CBD and clozabam work better together

“CBD and clobazam together, produced an anticonvulsant effect …that was greater than that observed with either CBD or clobazam alone.”

In new experimental research recently published in Epilepsia, Australian scientists explain their discovery that: “CBD and clobazam together, produced an anticonvulsant effect …that was greater than that observed with either CBD or clobazam alone.”

The researchers also said that the combination of clobazam and CBD “resulted in a lower proportion of mice experiencing spontaneous seizures than with clobazam alone.”