Cannabinoid repaired kidney damage

Could one day help cure renal disease by activating CB2 receptors in the kidney

Synthetic cannabinoid JWH-133 may be “a new therapeutic agent” in preventing kidney damage, according to experimental research published in Springer Nature’s December 2019 issue of Molecular and Cellular Biochemistry.

TRIGGERED UNIQUE BIOLOGICAL PROCESS

Led by medical researchers at two universities in Turkey, the experiment set in motion a unique process in the renal system of rats, and one that may open the door to eventual new treatments.

REDUCED INFLAMMATION

The study found that the cannabinoid reduced inflammation and helped protect/repair injured kidney tissue.

“JWH-133 may be a new therapeutic agent in preventing kidney IR damage,” the authors said.

NEW TREATMENTS MUST CONSIDER POSSIBLY HARMFUL AND BENEFICIAL EFFECTS

In 2017, a research paper published in America Journal of Renal Physiology, said the creation of new drugs to treat kidney disease requires a better understanding of cannabinoids – both plant-based and those naturally produced in the body – and their effects in humans – both positive and negative.

It said that cannabis could have both harmful and beneficial effects on the kidneys.

POTENTIAL DRUG DISCOVERIES

The paper’s authors, at universities in Tennessee and California, concluded that:

“…under certain circumstances” some cannabis-related products could be beneficial, “hence providing a novel potential area of drug discovery to address different forms of kidney disease.”

IMPORTANT EFFECTS ON KIDNEY FUNCTION

They also said that cannabis and cannabinoids could have “important effects on kidney function” but evidence from clinical research studies are needed to “determine the dangers faced by users of these products” with respect to acute kidney injury and chronic kidney disease.